Dextromethorphan a drug which is an analog of morphine and consist the main maopholine ring in its molecule which is also part of all opoid drungs.
It is found that the Sigma1 sites on the viral particles are bind with Dextromethorphan in a manner that helps virus to replicate.
Also the lysosome which impart cellular Imunity by embibing and dissolving viral particles, formed are smaller in size so that they are not effective against SARS-COV-2 viral particle vessicals.
Also there are some research findings on Opoid drugs usage and high mortality rate in patients given opoids for treatment of pain management.
Opoids are consided to be suppressing immunity ER lysosomal cellular protection mechanis is hampered by the Opoids.
There for treatment of SARS-COV-2 Positive patients drug that contains dextromethorphan or any opoidal anasthetic drug should be avoided, use of such agent should be done based on risk based approach.
On the other hand drug Haloperidol which is used in treatment of mental disorder is found to be blocking virus replication there for this drug may be a good candidate for the treatment of SARS-COV-2 .
Also these studies require Clinical evaluation through Clinical trials.
How ever looking at the reserch outcome it is recommended that dextromethorphan containg cough Syrup should be avoided for COVID 19 positive patients.
There are other Cough Syrups containing, Ambroxol, Guaphenasin, Bomohexine Hydrochloride Containg Cough Syrups, it should be started 5 ml Thice a day for positive patients even if there is no cough because it take three to four dose to show mucolytic activity, mucolytic activity is also hamper Virus growth and protect from damage to lungs due to coghing action.
Dextromethorphan should be contraindicated for COVId 19
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