This website is written by experts in Pharmaceutical Industry Manufacturing Research and Development and Regulatory Affairs Since 2008 and in 2011 Awarded as one of top 10 websites across world in Pharmaceutical Manufacturing Regulatory
USFDA WHO GMP Guidelines Pharmaceutical Regulations Information about Pharma Quality Managment System Validations Process Validation Cleaning Validation Equipment Qualification Equipment Process Validation Computer System Validation Sterile Product Manufacturing Guidelines Media fill guideline Aseptic Techniques in Sterile dosage form Clean Room Clean Room Classification Guidelines on Area Qualification HVAC AHU HEPA Filter HEPA Filter integrity testing and leak test

Sunday, October 7, 2012

Anti HIV drug nelfinavir exhibits anticancer activity against HER2 positive breast cancer cells

Anti-cancer activity of an anti retroviral drug:

Nelfinavir is a drug used in treatment of HIV infection to lower the HIV viral load. It is an enzyme inhibitor drug which inhibit an enzyme which breakdown protein from human cells in to in to small units, which are then used for formation of HIV viron capsule and rest of proteins responsible for activity of HIV. The enzyme is known as retroviral aspartyl protease, and the drug is known as protease inhibitor.

Simillar approach is also adapted in treatment of Hepatitis C and drugs used for the purpose are Boceprevir and Telaprevir.

The drug Nelfinavir is also being studied extensively for its activity against various cancer cell invitro, and it is found that it can facilitate killing of cancer cell (Apoptosis) when combined with radiation therapy.

Breast cancer is one of big reason for loses of lives in world wide of which breast cancer which is positive of Human Epidermal Growth Factor Receptor 2 is most difficult to treat and its progression is rapid.

Researchers at Johns Hopkins School of Medicine have studied effect of Nelfinavir on HER2 positive breast cancer in vitro over which they found satisfactory and later on confirmed the same in mice model, the concentration of drug required to bring about anticancer activity is almost similar to the existing dosage required for its antiretroviral activity.

This finding can be explored to develop more effective drug for HER2 positive breast cancer by developing analog drugs similar to Nelfinavir.

Other protease inhibitor drugs are ritonavir, indinavir, amprenavir,saquinavir, nelfinavir.

No comments:

Pharma Guidelines Most Read

.

Readers Visit Number

This website is Authentic Source of Pharmaceutical Guidelines

This website is Authentic Source of Pharmaceutical Guidelines

Pharma Validations Quality Management System USFDA Guidelines WHO GMP Guidelines New Drug Update





This website consist of detail Information about Pharma Guidelines Pharma Regulatory Affairs USFDA Guidelines WHO Guidelines Pharmaceutical Quality Management System Pharma Validations Process Validation Cleaning Validation Equipment Qualification Equipment Process Validation Computer System Validation Sterile Product Manufacturing Guidelines Media fill guideline Aseptic Techniques in Sterile dosage form Clean Room Clean Room Classification Guidelines on Area Qualification HVAC AHU HEPA Filter HEPA Filter integrity testing and leak test