Custom Search

Thursday, August 9, 2012

New drugs research to reduce harmful effects of radiation therapy in cancer treatment.

Activated protein C found to reduce harmful effect of radiation therapy in animal model now can be developed for humans as well to provide protection against harmful effect of radiation therapy in treatment of cancer and accidental exposure to radiation.

Radiation therapy is one of very important line of treatment for cancer, radiation is used to kill cancer cells, radiation kills cancer cells by damaging DNA of cancer cell preventing them form further division and proliferation, and prevents them from spreading in other part of body.

While radiation is able to kill cancerous cells it do affect normal cells surrounding the cancerous tissue and harm normal body tissue. Tissue repair process and healing process is delayed, blood cell counts too are reduced which is responsible for development of weakness and illness.

The most deadly effect of radiation therapy is its affect on bone marrow and stem cells, the cells which serve as origin for all of our body tissues cells. Radiation affects normal cells which rapidly divide (damage to cells in hair follicle result in hair loss). Damage to stem cells in bone marrow can be very critical due to reduction in WBC and RBC’S and tissue repair process is delayed.

Other effects of radiation therapy are fibrosis , damage in side bowel , diarrhea and bleeding , memory loss , infertility , there are chances of occurrence of secondary cancer due to radiation therapy it self.

Scientists at University of Arkansas for Medical Sciences (Dr. Martin Hauer-Jensen ) and Cincinnati Children's Hospital Medical Center (Dr. Hartmut Geiger) , Blood Research Institute of Wisconsin (Dr. Hartmut Weiler) have studied how harmful effect of radiation therapy can be reduced, in an animal model study over mice.

In mice model they found that after irradiation there was an increase in activity of the thrombomodulin gene (Thbd) which is responsible for production of cell surface receptor which regulates blood cell production and other process.

Thrombomodulin gene (Thbd) is also known for stimulating formation of protein C , in all its a is a protective mechanism which protects normal tissue cells from harmful effect of radiation by rapid production of normal blood and other tissue cells.

Scientists found that mice were able to get protection from harmful effect of radiation when infused with protein C.

This finding now opens new field for development of drugs for preventing harmful effect of radiation therapy in treatment of cancer.

So far there is only one drug which is approved by FDA to treat and provide protection against harmful effect of radiation over salivary gland damage is amifostine (Ethyol®) this drug can protect salivary glands from damage from radiation therapy when given during radiation therapy. Amifostine neutralize harmful free radicals produced by radiation and alkylating agents as well.

You may also like this:

Protein which is responsible for cancer spread discovered An antisense RNA treatment or a drug could be designed to treat cancer efficiently and safely.

Novel Drugs: Cancer Chemotherapy Using Nanoparticles May Reduce Harmful Side Effects.

No comments:

How to successfuly activate and receive our articles on pharmaceuticals by E-Mail

Dear readers if you wish to receive our articles on pharmaceutical automatically into your email Inbox , as and when we write a new article over this website, then follow these 3 simple steps.

1.You should write your Email ID in the box provided and push the subscribe button

2.Enter the text code that we show you in a small new browser window after you enter your email ID.

3.Log in to your email and Check our verification email sent by "FEEDBURNER" , there you should verify the link we send you by email.

Enter your email address get our articles by email whenever this website is updated

Delivered by FeedBurner

Join the list of our readers from Universities ,Research and
Development centers Pharmaceutical Companies from all over the world.

Pharma Research Regulatory Guidelines Website
Texas Dallas, TX 75211 US
Email: Website:
Copyright © 2008-2020 all rights reserve