Sunday, April 22, 2012

Type 2 Diabetes : ChREBP-β gene could be new target for new drugs for treatment of Type 2 Diabetes

Type 2 diabetes development linked to higher expression of gene responsible for insulin resistance in fatty tissuse. 

Diabetes is a disease which is developed over the period of time, as glucose present in blood is not mobilized in to body tissue viz, fat cells and muscles. Increase blood glucose level disrupts normal health and lead towards development of subsequent diseases like hyper tension, aging and muscular weakness and so on.

Insulin is a hormone in our body which regulates mobilization of blood glucose in to muscle and fat cells, it act upon muscle and fatty tissue cells , adipose tissue cells and trigger activation of protein molecules called as Glucose transporter type4 GLUT4 which facilitate transportation of glucose in to fat and muscle cells in our body, where glucose is used a source of energy and for tissue building. 

There are following types of diabetes 
 Type 1 Diabetes: Pancreas is not able to produce sufficient amount of Insulin, it may be because of several genetic factors and autoimmune diseases where cells producing insulin in pancreases are destroyed.

Type 2 Diabetes: In this type of diabetes peripheral muscle cells and fat cells produce resistance towards action of insulin or effect of insulin with respect to transportation of glucose is reduced, which is also related to Glucose transporter type 4 GLUT4.

Drs. Barbara Kahn and Mark Herman from Harvard Medical School and Beth Israel Deaconess Medical Center and their team have found that a gene ChREBP-β expressed highly which can be related to insulin resistance.

The high concentration of Glucose transporter type 4 GLUT4 which is responsible for mobilization and fatty tissue building . is related to higher expression of gene responsible ChREBP, and its other form gene ChREBP-β which was found in high level in mice feed with high fat diet, and in adipose tissue of individuals with insulin resistance therefore can be related to development of insulin resistance and obesity.

Higher expression of ChREBP-β is related to insulin resistance in fatty tissue therefore in future it could be one of target for developing a new drug to treat type 2 diabetes.

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