In 2011 this blog was listed as one of the top 10 blog in pharma technical information it is popular amongst the pharmacists and pharma industry professionals. We have published very important and very useful information for pharma industry professionals.

Friday, April 28, 2023

Stem Cells use Cord blood stem cells treatment

Stem cell and regenerative medicine: What is stem cell therapy ? Which disease condition can be treated with stem cell therapy.
There are certain cells in our body known as stem cells can differentiate in to many different organ tissue cells and connective tissues (pluripotent cells), which make stem cells one of great tool in regenerative medicine in fact it is looked as wonder medicine, stem cell derived from chord blood cell or bone marrow can differentiate in to , neural cell , liver cell, muscle cells or osteoblast (bone cells), blood corpuscles and so on eventually they can develop in to all types of organs and connective tissue cells, blood cells in human body.

Even stem cells are capable of rendering normal life to a patient affected with disorders like blood cancer and other degenerative diseases by virtue of replacing faulty tissue cells with normal cells originated through transplanted stem cells.

Stem cells develop in to a particular tissue basal cell which are called as pluripotent stem cells and progenitor cell which further develop in to cells of particular organ . This is one of our natural repair system of our body tissue. Stem cells can also be artificially grown in laboratory in to specific required tissue basal cells and injected in to damaged tissue where they bring repair of that damaged tissue, because this stem cells are used as source of regeneration of any damaged tissues or undeveloped tissues Or to bring about repair of an abnormal or the faulty tissue, as that in blood cancer.

Stem cells are classified in to two types
1) Embryonic stem cells are obtained from blastocysts (embryo)
2) Adult stem cells are present in all tissues.

Source of stem cells in human body:
Bone marrow and umbilical cord blood are main source of stem cells.

Cord blood stem cells:
Cord blood is a rich source of stem cells as well as hematopoietic cells , it is collected from the blood tissue in placental blood in umbilical cord after child birth, it is used in treatment of genetic disorders and hematopoietic disorders (blood disorders) as well as for regenerative therapies in tissue damages cord blood stem cells contains can be used to treat hematopoietic , degenerative disorders to some extent and genetic disorders.

Umbilical cord blood cells can be stored in cord blood stem cell banks, immediately after child birth, and can be used as a rich source of stem cells in future in event of any degenerative or hematopoietic disorders.
Adult stem cells are stem cells which are derived from the

Bone marrow stem cells mesenchymal:
Stroma in bone marrow consist of stem cells which are capable of differentiating in to basal cells (progenitor cell) of any organ or tissue in human body, and function as repair system in our body.
As the bone marrow stem cells also known as mesenchymal stem cells are capable of differentiating in to many different functional cells including osteoblasts (bone cells) which can develop in to particular tissues, therefore they are called as multipotent cells.

The cord blood stem cells are used to treat following disease
1) Hematological malignancies
2) Beta Thalassemia
3) Failure of Bone marrow
4) Adrenoleukodystrophy Nervous system damage of myelin sheet damage to peripheral nervous system and adrenal gland.( X-linked Adrenoleukodystrophy)
5) Inherited Immunodeficiency
6) Globoid Leukodystrophy
7) mucopolysaccharidosis type I disease a genetic disorder where there is lack of enzyme responsible for breakdown of mucopolysaccharides in lysosomes which gradually results in glycosaminoglycans buildup and organ damage.

Why chord blood is stored or banked information about cord blood?
Stem cells are cells which when injected in to damaged tissue, can repair that damaged tissue even they can promote growth of a organ otherwise not completely developed.

Chord blood is one of rich source of such stem cells hence when stored with stem cell or chord blood cell banks which adapt special procedures, can help in future in event baby require any regenerative treatment, stem cells from obtained from chord blood are isolated and grown and injected in to body , which then can repair or bring about development of tissue, even in case of injuries they are found to be effectively curing serious injuries.
Cord blood is derived from blood in placental blood vessel and umbilical chord blood vessels .
If one don not use it for self chord blood cells can be donated to other needy patient or can be used by for child or his second degree relatives

In united state US FDA regulate chord blood cell banking, it has lay down regulation about qualification of donor , storage, handling and processing, recovery, manufacturing , distribution labeling and packaging of human cells, tissues and cellular and tissue-based products (HCT/Ps) and chord blood cell banks. Organisations or chord blood cell banks are required to be registered with US FDA, which in turn monitor their procedure and facility for compliance with requirements, banks which provide chord blood cell products are required to provide detail about manufacturing , processing and storage labeling and distribution donor qualification , which involves screening of donor for any genetic and viral diseases.

Regulatory aspects of human tissue cell products

In united states chord blood cell and similar cell therapy and tissue products are regulated through CFR 21 Part 1271.
Also following regulatory requirements are mandatory for human tissue and cell products.
1)Labeling as under 21 CFR Parts 201, and 610 Subpart G
2) Regulations for Prescription Drug Advertising as under 21 CFR Part 202
3) Current good manufacturing practices regulations as under 21 CFR Parts 210 and 21 CFR Part 211
4) General Regulations for Biological Products: 21 CFR Part 600 –; and
5) Regulation of General Biological Products Standards as under 21 CFR Part 610.

You may also like
HEMACORD Cord blood Cell Stem Cell product approved by US FDA

Microbial load limits for water for pharmaceutical use

Ultraviolet light as antimicrobial disinfectant in water for pharmaceutical use

Why water for pharmaceutical use is always kept in close loop in continuous circulation?

Ion exchange resin and its application in pharmaceutical dosage forms, and drug delivery systems.

Why Betalactam Antibiotics require a separate manufacturing aria in a pharmaceutical manufacturing company?

Chemistry behind the allergic reactions and mode of action of betalactum antibiotics

US FDA approved first oral drug to reduce Multiple Sclerosis MS relapses

US FDA limits dosage of acetaminophen to 325 mg per unit dosage form,Requires boxed warning on lables.

US FDA honours woman who rejected thalidomide and saved millions of children's from thalidomide

A Pharmaceutical exceipent Beta Cyclodextrin being used in a life saving treatment

Nanoparticles of insulin in place of painful injections in treatment for diabetes patients, transdermal , nasal drug delivery systems

Corifact becomes the first drug to treat congenital deficiency of Factor XII.

Protein which is responsible for cancer spread discovered An antisense RNA treatment or a drug could be designed to treat cancer efficiently and safely.

Novel Drugs: Cancer Chemotherapy Using Nanoparticles May Reduce Harmful Side Effects.

What is Nanotechnology, its applications in medicine and pharmaceuticals, drug developments?

Good manufacturing practices

Pharma sales jobs Find best pharmaceutical company Job

What is Therapeutic Index ?

What is Narrow Therapeutic Range Drug?

What is High Efficiency Particulate Air( HEPA ) filter ?

What is a Laminar Air Flow Cabinet.

What is an Isolator in pharmaceutical manufacturing.?

What is 21 CFR Part 11, US FDA compliance and CFR 21 Part 11?

CFR 21 part 11 and its application on computarised systems used in clinical trials US FDA guidelines
Pharmaceutical Validation

Types of validations in pharmaceutical manufacturing

Requirements of documents for validation of sterilisation process

Clean Room Classification

Find a Job in Pharmaceutical Company -->JOBS IN PHARMA INDUSTRY<---

Quality assurance in pharma industry

Quality by design concept for pharmaceutical industry

Quality by design concept in pharmaceutical industryan explanation

No comments:

What is 21 CFR Part 11, US FDA guidelines requirements of FDA compliance and CFR 21 Part 11.

What is a Site Master file of a pharmaceutical company

What is Generic Drug

What is Reference Listed Drug  ? ( RLD )

What is Pharmaceutical Equivalents

What is Pharmaceutical Alternatives

What is Therapeutic Equivalents

What are Post Market studies

Why a drug is bound to protein, What is protein binding?  What is drug absorption , distribution ?

Do Physical properties contribute to drug activity.

What is drug receptor , How a drug resistance occurs

Mechanism of drug resistance

What is drug interaction

Drug interaction, and its examples

What is first pass metabolism of a drug

What is What is 510(k) Clearances ?

What is 510(k) Clearances,

Premarket Notification for medical devices - PMN or 510(k)

What is a drug interaction

Examples of drug interactions

Antibiotic Definition and classification

Antibiotic Resistance and Antibiotic resistance mechanism

Antioxidants food supplements

Vitamin D Details on FDA cautions on accurate dosage of Vitamin D

What is an antibody? what is monoclonal and polyclonal antibodies?

Terminologies In vaccine Production

Multi stage testing of Virus vaccine production

Testing of vaccines at different stages of production


Enzyme linked immunosorbent assay ELISA

Raido Immuno assay

Pharmaceutical Aseptic Manufacturing Process Terms , Terminology and Definitions.

Here are some articles which will be useful for you in further understanding of aspects of sterile dosage form manufacturing and regulatory affairs and good manufacturing practice in

pharmaceutical industry

Pharmaceutical Validation

Types of validations in pharmaceutical manufacturing

Requirements of documents for validation of sterilisation process

How to investigate OOS out of specification results

Determination of Phenol coefficient of a disinfectant

Sterility testing

Clean Room Classification

Time limitations in sterile pharmaceuticals processing

Aspects of validation of manufacturing process in sterile pharmaceuticals

Clinical Trials

Requirements of US FDA Inspections of Clinical Investigators of Clinical Trials




Controlling Pyrogens in injectable dosage forms

Media fill run process simulation aspects Validation of Aseptic Process and Sterilisation

New Drug Application (NDA) how to make a New Drug Application (NDA) to US FDA

Abbreviated New Drug Application (ANDA) What is ANDA , detailed information about ANDA preparation and submission to US FDA

How to make Investigational New Drug (IND) Application to US FDA

Drug applications submission to us fda Over the counter Drugs OTC drugs


Electronic record in pharmaceutical manufacturing industry

Good manufacturing practice in pharmaceutical industry

Pharmaceutical industry pharmaceutical companies and FDA latest updates