This website is written by experts in Pharmaceutical Industry Manufacturing Research and Development and Regulatory Affairs Since 2008 and in 2011 Awarded as one of top 10 websites across world in Pharmaceutical Manufacturing Regulatory
USFDA WHO GMP Guidelines Pharmaceutical Regulations Information about Pharma Quality Managment System Validations Process Validation Cleaning Validation Equipment Qualification Equipment Process Validation Computer System Validation Sterile Product Manufacturing Guidelines Media fill guideline Aseptic Techniques in Sterile dosage form Clean Room Clean Room Classification Guidelines on Area Qualification HVAC AHU HEPA Filter HEPA Filter integrity testing and leak test

Thursday, August 18, 2011

Scientists found the gene responsible for uncontrolled growth of body parts.


Drug or a gene therapy can be developed to control abnormal protein (AKT) activity responsible for uncontrolled body parts in Proteus Syndrome.

Life goes on with the hope of better tomorrow and our scientists and institutions too are tested by challenges of finding a treatment for diseases which still do not have any medicine or treatment to treat life threatening diseases, one of such disease is Proteus Syndrome.

It’s a great pain for parents and relatives of a child who’s body do not grow in the proportion it has to grow as normal, some children’s one limb grow larger than other or a hand palm growing in to its size beyond control, such disease also bring about deformities in bones and many times require amputation leading to permanent disability, one of such disease is known Proteus Syndrome.

Scientists from United States, National institute of health’s National Human Genome Research Institute (NHGRI) have found out the gene responsible for the Proteus Syndrome, after analyzing regions on DNA and exoms by whole-exome sequencing from affected patient and their family member , it was observed that a misspelled region in gene was found to be responsible for mutation.This misspelled gene is called as AKT1 which is also responsible for cancerous growths.It was also found that AKT proteins were more active in tissues of affected patients, with defective gene than in normal, the affected gene was also compared with huge DNA sequence data in libraries, and with affected patients, defective gene was a peculiar in affected patients only.Proteus Syndrome is believed to be developed after a spontaneous mutation in the gene.

There are now new possibilities open for such patients to treat them with gene therapy to replace affected gene, a drug can be developed to arrest the activity of AKT proteins in affected patients.
New biomarker identified which is linked to increased risk of kidney failure.

What is Antisense RNA ?  its application in medicine and new drug research and development

Novel Drugs: Cancer Chemotherapy Using Nanoparticles May Reduce Harmful Side Effects of

Protein which is responsible for cancer spread discovered

No comments:

Pharma Guidelines Most Read

.

Readers Visit Number

This website is Authentic Source of Pharmaceutical Guidelines

This website is Authentic Source of Pharmaceutical Guidelines

Pharma Validations Quality Management System USFDA Guidelines WHO GMP Guidelines New Drug Update





This website consist of detail Information about Pharma Guidelines Pharma Regulatory Affairs USFDA Guidelines WHO Guidelines Pharmaceutical Quality Management System Pharma Validations Process Validation Cleaning Validation Equipment Qualification Equipment Process Validation Computer System Validation Sterile Product Manufacturing Guidelines Media fill guideline Aseptic Techniques in Sterile dosage form Clean Room Clean Room Classification Guidelines on Area Qualification HVAC AHU HEPA Filter HEPA Filter integrity testing and leak test