What is drug receptors How drug resistance occurs explanation on drug receptor theory

What is drug receptors? How drug resistance occurs, explaination on the basis of drug receptor theory:
Drug receptors are the sites on the tissues or proteins or enzymes or on cell wall or cell organelles of microorganisms where a drug gets attached to a particular site. These receptor sites are specific to a particular drug, drugs bind to this receptor through covalent or hydrogen bonding or ionic bonding and this binding is responsible for further physicochemical events which impart a desired effect of a drug.
Physicochemical events as discussed in earlier are due to inhibition or activation or agonistic action , or just by physical properties of a drug molecule , on the particular receptor site.

Reasons why these receptor sites are specific:
The drugs are designed with the intention of mimicking the chemical structures of biochemicals in our body that may be an amino acid sequence of an enzyme which takes part in any biochemical reaction, or a modification of a atomic group of an naturally occurring metabolite , (Anti metabolite drugs).

1. Drug molecules may mimic naturally occurring enzyme or biochemical’s so that the drug is taken up by the biochemical path way reaction systems.

2. Drug molecule may mimic as agonist to which brig about activation of the path way.

3. Drug molecule may mimic as antagonist which bring about Inhibitory actions.
The receptors are just the complementary points on the systems where a drug is suppose to impart its desired action, these points may be multiple for a drug, as a Azo nitrogen, or carboxylic acid group on a drug taking part in the reaction, or a drug molecule hindering the naturally occurring enzyme or a biochemical molecule from taking part in its normal reaction path way ,owning to its stearic hindrance or spatial arrangement around the receptor site .

Hence the drug receptors are unique for particular drugs.

Drug resistance and Receptors
In case of an resistance the receptor sites changes its orientation , than the earlier one , or it changes the affinity towards a particular bio molecule so that the drug molecule do not bind to the receptor site , may drugs act competitively so the naturally occurring biochemical’s concentrations (Enzyme Induction ) increases .
We have written other phenomenon’s of drug resistance in details over here

We have tried to answer a question of one of a reader of this website as short as possible;
You too can ask us a questions by writing us to submitearticles(@)gmail.com .
We will answer your questions on this website.

=======================================================================
Do you know now this website has become a most popular and most referred website in pharmaceutical industry and pharma companies all over the world ,for allmost all topics related to Pharmaceutical Manufacturing , Pharmaceutical Regulatory Affairs and Good Manufacturing Practice and latest and new drugs.
=======================================================================
What is What is 510(k) Clearances ?
What is 510(k) Clearances, Premarket Notification for medical devices - PMN or 510(k)


Antibiotic Definition and classification


Antibiotic resitance and Drug resistance mechanism

Antioxidants food suppliments

Vitamin D Details on FDA cautions on accurate dosage of Vitamin D


What is an antibody? what is monoclonal and polyclonal antibodies?


Enzyme linked immunosorbent assay ELISA

Raido Immuno assay
http://whoguideline.blogspot.com/2010/04/terminalogy-and-their-explanations.html

Pharmaceutical Aseptic Manufacturing Process Terms , Terminology and Definations.

http://whoguideline.blogspot.com/2010/02/pharmaceutical-aseptic-manufacturing.html

Here are some articles which will be useful for you in further understanding of aspects of sterile dosage form manufacturing and regulatory affairs and good manufacturing practice in pharmaceutical industry

Pharmaceutical Validation

Types of validations in pharmaceutical manufacturing

Requirements of documents for validation of sterilisation process

How to investigate OOS out of specification results

Determination of Phenol coeeficient of a disinfectant

Sterility testing

Cleen Room Classification

Time limitations in sterile pharmaceuticals processing

Aspects of validation of manufacturing process in sterile pharmaceuticals

Clinical Trials

Controling Pyrogens in injectable dosage forms

Media fill run process simulation aspects Validation of Aseptic Process and Sterilisation

New Drug Application (NDA) how to make a New Drug Application (NDA) to US FDA

Abbreviated New Drug Application (ANDA) What is ANDA , detaied information about ANDA preparation and submission to US FDA

How to make Investigational New Drug (IND) Application to US FDA

Drug applications submission to us fda Over the counter Drugs OTC drugs

BIOAVAILABILITY AND BIOEQUIVALENCE REQUIREMENTS

Eletronic record in pharmaceutical manufacturing industry

Good manufacturing practice in pharmaceutical industry

Pharmaceutical industry pharmaceutical companies and FDA latest updates

Here is an intresting article on world wide pharmaceutical industry
Article on Pharmaceutical Industry pharmaceutical industry

Here are some interesting articles on Quality assurance systems for pharmaceutical company
1.Quality assurance in pharma industry

2.Quality by designe concept for pharmaceutical industry

3.Quality by designe concept in pharmaceutical industryan explanation