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Sunday, August 8, 2010

PHARMACOLOGY,PHARMCY SUBJECTS,THEIR TOPICS AND TEXT BOOKS AND REFERANCE BOOKS

PHARMACOLOGY,PHARMCY SUBJECTS,THEIR TOPICS AND TEXT BOOKS AND REFERANCE BOOKS
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PHARMACOLOGY
Text books (Theory)
a. Tripathi, K. D. Essentials of medical pharmacology. 4th edition, 1999. Publisher: Jaypee, Delhi.
b. Satoskar, R.S. and Bhadarkar, S.D. Pharmacology and pharmacotherapeutics. 16th edition (single volume), 1999. Publisher: Popular, Dubai.
c. Rang, H.P. and Dale, M.M. Pharmacology. 4th edition, 1999. Publisher: Churchill Living stone.

Reference books (Theory)
a. Goodman Gilman, A., Rall, T.W., Nies, A.I.S. and Taylor, P. Goodman and Gilman’s The pharmacological Basis of therapeutics. 9th edition, 1996. Publisher: Mc Graw Hill, Pergamon press.
b. Craig, C.R. and Stitzel, R.E. Modern Pharmacology. Latest edition. Publisher: Little Brown and company.
c. Katzung, B.G. Basic and clinical pharmacology. Latest edition. Publisher: Prentice Hall,International.
d. Gupta, P.K. and Salunkhe, D.K. Modern Toxicology. Volume I, II and III. Latest edition. Publisher: B.V. Gupta, Metropolitan Book Co. (p) Ltd, New Delhi.
Text books (Practical)
Kulkarni, S. K. and Dandia, P. C. Hand book of experimental pharmacology. Latest edition, Publisher:
Vallab, Delhi.

Reference books (Practical) :
a. Macleod, L.J. Pharmacological experiments on intact preparations. Latest edition, Publisher: Churchill livingstone.
b. Macleod, L.J. Pharmacological experiments on isolated preparations. Latest edition, Publisher: Churchill livingstone.
c. Ghosh, M.N. Fundamentals of experimental pharmacology. Latest edition, Publisher: Scientific book agency, Kolkata.
d. Ian Kitchen. Textbook of in vitro practical pharmacology. Latest edition, Publisher: Black well Scientific.
Text books (Theory)

(Author, Title, Edition, Publication Place, Publisher, Year of Publication)

a. Tripathi, K. D. Essentials of medical pharmacology. 4th Ed, 1999. Publisher: Jaypee, Delhi.
b. Satoskar, R.S. and Bhadarkar, S.D. Pharmacology and pharmacotherapeutics. 16th edition (single
volume), 1999. Publisher: Popular, Dubai.
c. Rang, H.P. & Dale, M.M. Pharmacology. 4th edition, 1999. Publisher: Churchill Living stone.

Reference books (Theory)(Author, Title, Edition, Publication Place, Publisher, Publication Year)
a. Goodman Gilman, A., Rall, T.W., Nies, A.I.S. and Taylor, P. Goodman and Gilman’s The
pharmacological Basis of therapeutics. 9th Ed, 1996. Publisher Mc Graw Hill, Pergamon press.
b. Craig, C.R.&Stitzel, R.E. Modern Pharmacology. Latest edition. Publisher: Little Brown.Co
c. Katzung, B.G. Basic and clinical pharmacology. Latest edition. Publisher: Prentice Hall, Int.
d. Shargel and Leon. Applied Biopharmaceutics and pharmacokinetics. Latest edition. Publisher:
Prentice Hall, London.

Text books (Practical) :
Kulkarni, S. K. and Dandia, P. C. Hand book of experimental pharmacology. Latest edition,Publisher: Vallab, Delhi.
Reference books (Practical)
a. Macleod, L.J. Pharmacological experiments on intact preparations. Latest edition, Publisher: Churchill livingstone.
b. Macleod, L.J. Pharmacological experiments on isolated preparations. Latest edition, Publisher: Churchill livingstone.
c. Ghosh, M.N. Fundamentals of experimental pharmacology. Latest edition, Publisher: Scientific book agency, Kolkata.
d. Ian Kitchen. Textbook of in vitro practical pharmacology. Latest edition, Publisher: Black well Scientific.

Topic
1. General Pharmacology
a) Introduction, definitions and scope of pharmacology
b) Routes of administration of drugs
c) Pharmacokinetics (absorption, distribution, metabolism and excretion)
d) Pharmacodynamics
e) Factors modifying drug effects
f) Drug toxicity - Acute, sub- acute and chronic toxicity.
g) Pre-clinical evaluations
h) Drug interactions

2. Pharmacology of drugs acting on ANS
a) Adrenergic and antiadrenergic drugs
b) Cholinergic and anticholinergic drugs
c) Neuromuscular blockers
d) Mydriactics and miotics
e) Drugs used in myasthenia gravis
f) Drugs used in Parkinsonism
3. Pharmacology of drugs acting on cardiovascular system
a) Antihypertensives
b) Anti-anginal drugs
c) Anti-arrhythmic drugs
d) Drugs used for therapy of Congestive Heart Failure
e) Drugs used for hyperlipidaemias
4. Pharmacology of drugs acting on Central Nervous System
a) General anesthetics
b) Sedatives and hypnotics
c) Anticonvulsants
d) Analgesic and anti-inflammatory agents
e) Psychotropic drugs
f) Alcohol and methyl alcohol
g) CNS stimulants and cognition enhancers
h) Pharmacology of local anaesthetics
5. Pharmacology of Drugs acting on Respiratory tract
a) Bronchodilators
b) Mucolytics
c) Expectorants
d) Antitussives
e) NasalDecongestants
6. Pharmacology of Hormones and Hormone antagonists
a) Thyroid and Antithyroid drugs
b) Insulin, Insulin analogues and oral hypoglycemic agents
c) Sex hormones and oral contraceptives
d) Oxytocin and other stimulants and relaxants
7. Pharmacology of autocoids and their antagonists
a) Histamines and Antihistaminics
b) 5-Hydroxytryptamine and its antagonists
c) Lipid derived autocoids and platelet activating factor


3. Topic
1. Pharmacology of Drugs acting on Blood and blood forming agents
a) Anticoagulants
b) Thrombolytics and antiplatelet agents
c) Haemopoietics and plasma expanders

Pharmacology of drugs acting on Renal System
a) Diuretics
b) Antidiuretics
3. Chemotherapy
a) Introduction
b) Sulfonamides and co-trimoxazole
c) Penicillins and Cephalosporins
d) Tetracyclins and Chloramphenicol
e) Macrolides, Aminoglycosides, Polyene & Polypeptide antibiotics
f) Quinolines and Fluroquinolines
g) Antifungal antibiotics
h) Antiviral agents
i) Chemotherapy of tuberculosis and leprosy
j) Chemotherapy of Malaria
k) Chemotherapy of protozoal infections (amoebiasis, Giardiasis)
l) Pharmacology of Anthelmintic drugs
m) Chemotherapy of cancer (Neoplasms)
4 Immunopharmacology
Pharmacology of immunosuppressants and stimulants
5. Principles of Animal toxicology
Acute, sub acute and chronic toxicity
6. The dynamic cell: The structures and functions of the components of the
cell
a) Cell and macromolecules: Cellular classification, subcellular organelles,macromolecules, large macromolecular assemblies
b) Chromosome structure: Pro and eukaryotic chromosome structures,
chromatin structure, genome complexity, the flow of genetic information.
c) DNA replication: General, bacterial and eukaryotic DNA replication.
d) The cell cycle: Restriction point, cell cycle regulators and modifiers.
e) Cell signaling: Communication between cells and their environment, ionchannels,signal transduction pathways (MAP kinase, P38 kinase, JNK, Ras
and PI3-kinase pathways, biosensors.

The Gene: Genome structure and function:
a) Gene structure: Organization and elucidation of genetic code.
b) Gene expression: Expression systems (pro and eukaryotic), genetic elements
that control gene expression (nucleosomes, histones, acetylation, HDACS,
DNA binding protein families.
c) Transcription and Transcription factors: Basic principles of transcription in
pro and eukaryotes. Transcription factors that regulate transcription in pro
and eukaryotes.
RNA processing: rRNA, tRNA and mRNA processing.
Protein synthesis: Mechanisms of protein synthesis, initiation in eukaryotes,
translation control and post-translation events
Altered gene functions: Mutations, deletions, amplifications, LOH,
traslocations, trinucleotide repeats and other genetic abnormalities. Oncogenes
and tumor suppressor genes.
The gene sequencing, mapping and cloning of human disease genes.
Introduction to gene therapy and targeting.
Recombinant DNA technology: principles. Processes (gene transfer technology)
and applications

Books:
1 Molecular Biology of the Cell by Alberts B., Bray, D., Lewis, J., Raff M., Roberts, K and Watson,
JD, 3rd edition.
2 Molecular Cell Biology By Lodish, H., Baltimore, D., Berk, A et al., 5th edition.
3 Molecular Biology by Turner, PC., McLennan, AG., Bates, AD and White MRH 2nd edition.
4 Genes VIII by Lewin, B., (2004)
5 Pharmaceutical Biotechnology, by Crommelin, DJA and Sindelar RD (1997)
6 Recombinant DNA by Watson, JD., Gilman, M., et al., (1996)
7 Biopharmaceutical: Biochemistry and Biotechnology by Walsh, G., (1998)

PHARMACOLOGY (PRACTICAL)
1. Study of laboratory animals and their handling (a. Frogs, b. Mice, c. Rats, d. Guinea pigs, e. Rabbits).
2. Study of physiological salt solutions used in experimental pharmacology.
3. Study of laboratory appliances used in experimental pharmacology.
4. Study of use of anesthetics in laboratory animals.
5. To record the dose response curve of Ach using isolated ileum/rectus abdominis muscle preparation.
6. To carry out bioassay of Ach using isolated ileum/rectus abdominis muscle preparation by interpolation method.
7. To carry out bioassay of Ach using isolated ileum/rectus abdominis muscle preparation by three point method.
8. To record the dose response curve of Histamine using isolated guinea-pig ileum preparation.
9. Study of agonistic and antagonistic effects of drugs using isolated guinea-pig ileum preparation.
10. To carry out bioassay of Histamine using isolated guinea-pig ileum preparation by interpolation method.
11. To carry out bioassay of Histamine using guinea-pig ileum preparation by three point method.
12. To study the routes of administration of drugs in animals (Rats, Mice, Rabbits).
13. Study of theory, principle, procedure involved and interpretation of given results for the following experiments:
a) Analgesic property of drug using analgesiometer.
b) Antiinflammatory effect of drugs using rat-paw edema method.
c) Anticonvulsant activity of drugs using maximal electroshock and pentylene tetrazole methods.
d) Antidepressant activity of drugs using pole climbing apparatus and pentobarbitone induced sleeping time methods.
e) Locomotor activity evaluation of drugs using actophotometer and rotorod.
f) Cardiotonic activity of drugs using isolated frog heart and mammalian heart preparations.

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