Custom Search

Friday, April 17, 2009

Ringer solution intravenous Injection formulation aspects

Ringer solution for intravenous Injection formulation aspects how to calculate milli equivalance for labe claim .
1. “Injection should not be used if it contains visible solid particle”.
This preparation is used in tetretment extracellular volume depletion, sodium depletion, dehydration, concentration, infused is 0.9% which is isotonic with plasm, 0.45% is infused in conjunction with dextrose. Hypertonic solution 3 – 5 % is used in emergency condition of Na-depletion, Kcl is infused in case of acute hypocalaemia, it is infused along with Nacl and dextrose, used as source of k+, kcl is highly irritant during administration case has to be taken for extra vasatation, ca-gluconate is less irritant used in such cond’n.

Ringer solution for intravenous Injection contains not less than 0.82% not no more than 0.89% w/v ; not less than 0.0285% and n.m.t.0.0315% w/v kcl and N.L.T. 0.03 % w/v of Ca++ N.M.T. 0.036% w/v of calcium chloride .2H2O it contains no. antimicrobial agents.

Ingredients Qty taken for study

Sodium chloride 4.64 gm.
Potassium chloride 0.162 gm.
Calcium 8.171 gm.
Water for injection QS 540ml.

Manufacturing Procedure: Dissolve the ingredients in water for in jet filter until clear sterilize by heating in autoclave, filter thorough 0.20 micron or G-3 sentered glass filter

PH = 5 to 7.5

Storage: Stored in single dose container of glass or plastic.
Route of administration: Intravenous.
Category: Fluid and electrolyte replanihser.
Label should state mill.eqivalent of ions per liter.

How to calculate milliequivalent of Ions in given
Eq. wt = At Wt or Mol Wt /Valancy of salt = 1000 milli eq. wt.

Milli equiventent ofions in salt is Equivalent weight of ions expressed in miligram.
Mol wt of Nacl --- 58.5g.
Therefore 58.5 gm.Nacl = 23 gm. Na+
Therefore 8.6gm. Nacl = 3.338gm.

No comments:

How to successfuly activate and receive our articles on pharmaceuticals by E-Mail

Dear readers if you wish to receive our articles on pharmaceutical automatically into your email Inbox , as and when we write a new article over this website, then follow these 3 simple steps.

1.You should write your Email ID in the box provided and push the subscribe button

2.Enter the text code that we show you in a small new browser window after you enter your email ID.

3.Log in to your email and Check our verification email sent by "FEEDBURNER" , there you should verify the link we send you by email.

Enter your email address get our articles by email whenever this website is updated

Delivered by FeedBurner

Join the list of our readers from Universities ,Research and
Development centers Pharmaceutical Companies from all over the world.

Pharma Research Regulatory Guidelines Website
Texas Dallas, TX 75211 US
Email: Website:
Copyright © 2008-2020 all rights reserve