Custom Search

Friday, April 17, 2009

Normal saline Formulation

Formulation of Normal salaine
It is a sterile solution of sodium chloride and dextrose in water for injection. It contains not less than 90% and not less than 105% of stated amount of Nacl and dextrose.
Usual strength: Injection containing following amounts of Nacl and unhydrous dextrose.

Conc. and dosage of Nacl are determined by clinical state like age, sex, etc. 0.9% is used in Na+ and in water depletion, metabolic alkalosis, Haemodialysis and peritoneal dialysis, 0.4% used along c dextrose as replacement for fluid electrolyte and carbohydrate in pat ient, unable to take oral food.
Hypertonic sol’n of Nacl rarely used in emergency condition like acute Na+
Depletion Dextrose 5% used in most cases of hypoglycemic coma and cerebral edam or infused through central vein.
Solution when autoclared should not be over heated Dextrose on decomposition give 5 hydroxy furfural lave tonic acid, furfural derivative polymerizes give dark brow colour because of laveolonic acid ph is drooped below.
We should keep PH of intravenous Normal salaine between 3.5 to 6.5
Finding isotonic formulation
Nacl 0.45% Dextrose 2.5% is a Isotonic combination
It should be stored in cool place
Labeling should maintain % w/v of Nacl and dextrose concentration , concentration of Na+ and cl+ In milliequivalece per 1000 ml

No comments:

How to successfuly activate and receive our articles on pharmaceuticals by E-Mail

Dear readers if you wish to receive our articles on pharmaceutical automatically into your email Inbox , as and when we write a new article over this website, then follow these 3 simple steps.

1.You should write your Email ID in the box provided and push the subscribe button

2.Enter the text code that we show you in a small new browser window after you enter your email ID.

3.Log in to your email and Check our verification email sent by "FEEDBURNER" , there you should verify the link we send you by email.

Enter your email address get our articles by email whenever this website is updated

Delivered by FeedBurner

Join the list of our readers from Universities ,Research and
Development centers Pharmaceutical Companies from all over the world.

Pharma Research Regulatory Guidelines Website
Texas Dallas, TX 75211 US
Email: Website:
Copyright © 2008-2020 all rights reserve