The physical properties of a drug do affect the pharmacological activity; Physical properties are secondary properties of any drug, which are resultant of the chemical properties of that drug.
For example solubility of any of drug depends up on the chemical structure, rather its constituent atoms and bonding impart intramolecular hydrogen bonding and polarity, atom and bonding polarity in turn decides spacial orientation of that drug molecule and crystal characteristics and solubility. Spacial orientation we all study in stereochemistry, or orientation of drug molecule, is important as it may hinder or enhance the approach and attachment of a drug molecule to its receptor.
The drug molecule acts on a particular site (receptor) when it reaches that point, and this we call as availability of that drug at the point of action, we call it as bioavailability.
Physical properties of a drug molecule are very important in achieving solubility in the biological medium , if the drug is very much soluble in water it is bound to be excreted faster and the point of actions which it may act will be restricted to the tissues which are abundant of fluids , and if a drug is lipid soluble it is more likely that it will get absorbed in to the fatty tissues more rapidly like nervous system and brain , and tissues with high lipid content , thus the abortion of such drugs is faster in such tissues action is faster on such tissues , example of such drugs are tricyclic anti depressant which they have a common tricyclic rings which impart lipid solubility.
Both properties have their own advantages and disadvantages, one will not facilitate quicker absorption while other enhance absorption and excretion and so the half life of the blood concentration.
Physiological activity is some thing we can say the consequences of attachment of a drug molecule to its receptor, these may be
Example: Enzyme Inhibition (Competitive or complete)
2. Activation, or agonistic action
Drug can act as if it is a part of our body’s biochemical process or reactions there by there by bringing about a desired biochemical reaction which may help our body to maintain normal biochemical activities.
3. Synergistic action, drug may enhance the ability of the particular enzyme of hormone or protein to produce more activity.
We have tried to answer a question of one of a reader of this website as short as possible;
You too can ask me questions by writing me to submitearticles(@)gmail.com .
We will answer your questions on this website.
Do you know now this website has become a most popular and most referred website in pharmaceutical industry and pharma companies all over the world ,for allmost all topics related to Pharmaceutical Manufacturing , Pharmaceutical Regulatory Affairs and Good Manufacturing Practice and latest and new drugs.
What is What is 510(k) Clearances ?
What is 510(k) Clearances, Premarket Notification for medical devices - PMN or 510(k)
Antibiotic Definition and classification
Antibiotic resitance and Drug resistance mechanism
Antioxidants food suppliments
Vitamin D Details on FDA cautions on accurate dosage of Vitamin D
What is an antibody? what is monoclonal and polyclonal antibodies?
Enzyme linked immunosorbent assay ELISA
Raido Immuno assay
Pharmaceutical Aseptic Manufacturing Process Terms , Terminology and Definations.
Here are some articles which will be useful for you in further understanding of aspects of sterile dosage form manufacturing and regulatory affairs and good manufacturing practice in pharmaceutical industry
Types of validations in pharmaceutical manufacturing
Requirements of documents for validation of sterilisation process
How to investigate OOS out of specification results
Determination of Phenol coeeficient of a disinfectant
Cleen Room Classification
Time limitations in sterile pharmaceuticals processing
Aspects of validation of manufacturing process in sterile pharmaceuticals
Controling Pyrogens in injectable dosage forms
Media fill run process simulation aspects Validation of Aseptic Process and Sterilisation
New Drug Application (NDA) how to make a New Drug Application (NDA) to US FDA
Abbreviated New Drug Application (ANDA) What is ANDA , detaied information about ANDA preparation and submission to US FDA
How to make Investigational New Drug (IND) Application to US FDA
Drug applications submission to us fda Over the counter Drugs OTC drugs
BIOAVAILABILITY AND BIOEQUIVALENCE REQUIREMENTS
Eletronic record in pharmaceutical manufacturing industry
Good manufacturing practice in pharmaceutical industry
Pharmaceutical industry pharmaceutical companies and FDA latest updates
Here is an intresting article on world wide pharmaceutical industry
Article on Pharmaceutical Industry pharmaceutical industry
Here are some interesting articles on Quality assurance systems for pharmaceutical company
1.Quality assurance in pharma industry
2.Quality by designe concept for pharmaceutical industry
3.Quality by designe concept in pharmaceutical industry an explanation